The World's #1 Dry Mouth Treatment. Biotene helps the millions who suffer from dry mouth with a variety of products that relieve discomfort. For over 20 years, Laclede, makers of Biotene, have been developing biological products which utilize the body's natural defense systems for the prevention and treatment of gum disease caused by dry mouth. While pioneering new biological approaches that can help the body strengthen its defense against harmful pathogens, Biotene continues to treat their customers with quality and care.